Vascular remodeling in sheep implanted with endovascular neural interface

SE John; S Donegan; TC Scordas; W Qi; P Sharma; K Liyanage; S Wilson; I Birchall; A Ooi; TJ Oxley; CN May; DB Grayden; NL Opie

Journal article

Vascular remodeling in sheep implanted with endovascular neural interface

SE John, S Donegan, TC Scordas, W Qi, P Sharma, K Liyanage, S Wilson, I Birchall, A Ooi, TJ Oxley, CN May, DB Grayden, NL Opie

Journal of Neural Engineering | IOP Publishing Ltd | Published : 2022

DOI: 10.1088/1741-2552/ac9a77

Abstract

Objective. The aim of this work was to assess vascular remodeling after the placement of an endovascular neural interface (ENI) in the superior sagittal sinus (SSS) of sheep. We also assessed the efficacy of neural recording using an ENI. Approach. The study used histological analysis to assess the composition of the foreign body response. Micro-CT images were analyzed to assess the profiles of the foreign body response and create a model of a blood vessel. Computational fluid dynamic modeling was performed on a reconstructed blood vessel to evaluate the blood flow within the vessel. Recording of brain activity in sheep was used to evaluate efficacy of neural recordings. Main results. Histol..

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Grants

Awarded by U.S. Department of Defense

Funding Acknowledgements

The authors would like to thank Mr G Rind and Mr S Ronayne for their assistance with the surgeries and in the device manufacture, and Mr T Dornom, Mr A McDonald, and Mr T Vale for surgical and animal handling assistance. This work was funded by the Australian Government through the National Health and Medical Research Council of Australia (NHMRC) Project Grant No. 1158912, US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office contract (N6601-12-1-4045); Office of Naval Research (ONR) Global (N6601-12-1-4045); US Department of Defence, Epilepsy Research Program CDMRP EP170058; Victorian Government, Department of Health and Human Services through the Victorian Medical Research Acceleration Fund and the Victorian Government's Operational Infrastructure Support Program. Mr Weijie Qi is funded by the China Scholarship Council (CSC) from the Ministry of Education of P. R. China, CSC No. 202008240002.